Archive for Publications

Selected CHERUB Publications

A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages

Mlcochova P, Sutherland KA, Watters, SA, Bertoli C, de Bruin RAM, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK

EMBO J. 2017 Jan 25; pii: e201696025. doi: 10.15252/embj.201696025. [Epub ahead of print]

A global survey of HIV-positive people’s attitudes towards cure research.

Simmons R, Kall M, Collins S, Cairns G, Taylor S, Nelson M, Fidler S, Porter K, Fox J; Collaborative HIV Eradication of viral Reservoirs (CHERUB) Survey collaboration.

HIV Med. 2016 May 11; doi: 10.1111/hiv.12391. [Epub ahead of print]

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.

Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, Meyerowitz J, Willberg C, Koelsch KK, Robinson N, Brown H, Fisher M, Kinloch S, Cooper DA, Schechter M, Tambussi G, Fidler S, Babiker A, Weber J, Kelleher AD, Phillips RE, Frater J.

Nat Commun. 2015 Oct 9;6:8495

Structured observations reveal slow HIV-1 CTL escape.

Roberts HE, Hurst J, Robinson N, Brown H, Flanagan P, Vass L, Fidler S, Weber J, Babiker A, Phillips RE, McLean AR, Frater J; SPARTAC trial investigators.

PLoS Genet. 2015 Feb 2;11(2):e1004914.

Advancing the HIV cure agenda: the next 5 years.

Thornhill J, Fidler S, Frater J.

Curr Opin Infect Dis. 2015 Feb;28(1):1-9.


Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infection.

Thornhill J, Inshaw J, Oomeer S, Kaleebu P, Cooper D, Ramjee G, Schechter M, Tambussi G, Fox J, Miro JM, Weber J, Babiker A, Porter K, Fidler S.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19480.


HIV-1 DNA predicts disease progression and post-treatment virological control.

Williams JP, Hurst J, Stöhr W, Robinson N, Brown H, Fisher M, Kinloch S, Cooper D, Schechter M, Tambussi G, Fidler S, Carrington M, Babiker A, Weber J, Koelsch KK, Kelleher AD, Phillips RE, Frater J; SPARTACTrial Investigators.

Elife. 2014 Sep 12;3:e03821.

New approaches in HIV eradication research

By John Frater

This review describes the major obstacles that need to be overcome and the key new advances and strategies designed to achieve an HIV cure. Although there is currently no cure for HIV infection, there has been a resurgence of interest in the field with the development of a number of potential new approaches, some of which have entered clinical trials.

New approaches in HIV eradication research
New approaches in HIV eradication research
Frater Curr Op Infec Dis 2011 24, 593.pdf
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