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CHERUB response to the recent media coverage regarding the RIVER trial

In response to the recent attention in the media regarding the RIVER study run by the UK CHERUB collaboration, we would like to clarify the following.

Our study will report in 2018, and until then we will not know if the intervention has had an effect. We do know from our first participant that the intervention was well tolerated. This is the first time that this combination has been given in a clinical trial, which we hope will be the first of many collaborations exploring HIV cure between our five universities and NHS hospital trusts, supported by the NIHR.

An important clarification is that all participants involved in the study will be expected to have no HIV in their blood because they are receiving antiretroviral therapy – these are the standard drugs we use to treat HIV. This does not mean they have been cured as some headlines have suggested. This does mean that their immune systems will recover and that they will not transmit the virus. We look forward to reviewing the final results of this ground-breaking study, but until then should emphasise that we cannot yet state whether any individual has responded to the intervention or been cured.

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HEATHER meeting 22nd September 2016

heather-logo

The HEATHER research team would like to invite you to attend a feedback meeting.

HEATHER (HIV reservoir targeting with Early Antiretroviral Therapy) is a study that has been set up to try and understand what happens to HIV when patients start treatment early after infection and remain on treatment for a long period of time.

This meeting will be an opportunity to show some of the laboratory results from the samples that have kindly been donated by the study participants as well as the research that is involved in this study. There will also be a chance to chat with the scientists and researchers who are working on this exciting and unique study.

When: 22 SEPTEMBER 2016, 6-7.30pm

Where: Room G64 and G65A – Medical School St Mary’s Campus.
The medical school is building number 5, and the main entrance is opposite the Cambridge Wing entrance. Please click on the link for directions:
https://www.imperial.ac.uk/visit/campuses/st-marys/

RSVP: Please confirm your attendance by 17 SEPTEMBER 2016

Snacks and drinks will be provided

We hope to see you there.

The HEATHER research team

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5th CHERUB Scientific Workshop Brochure

The fifth annual CHERUB Scientific Workshop took place on Friday 4th December 2015 at 170 Queens Gate, South Kensington Campus, Imperial College London.

To view the event brochure please click the image below.

Brochure

 

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RIVER trial – Research In Viral Eradication of HIV Reservoirs

RIVER Trial

Targeting the HIV ‘reservoir’ could be the first step to understanding how to cure the infection

The RIVER trial is now open for recruitment in the UK. It is one of the first clinical trials to test a new idea of how to cure HIV, through waking a ‘reservoir’ of cells infected with sleeping virus and killing them using the immune system. This idea has been called ‘Kick and Kill’ and this study will investigate if it might work.

The RIVER study is being conducted by the CHERUB collaboration, an alliance of HIV researchers at Oxford University, Imperial College London, the University of Cambridge, UCL, and King’s College London. The study is funded by the Medical Research Council with support from industry partners MSD and GSK.

There are 6 centres participating in RIVER: Royal Free Hospital, St Mary’s Hospital, Mortimer Market Centre, Royal Sussex County Hospital Brighton, Chelsea and Westminster Hospital and St Thomas’s Hospital.

The results of the RIVER study are expected in 2018.

Full article

If you would like to take part in the RIVER trial please see the MRC CTU at UCL website for more information.

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Reports of HIV ‘breakthrough’ and ‘cure’ are premature

“HIV breakthrough could lead to a cure,” the Mail Online says, reporting on a study which looked at the phenomenon known as post-treatment control – where people with HIV remain in remission, even after treatment with antiretroviral (ARV) drugs is withdrawn.”

“Talks of a cure are far too premature, but finding out about what does and doesn’t help lead to post-treatment control, and so prevent viral rebound, is always going to be useful.”

Read the full article on NHS Choices here.

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