Archive for February 17, 2020

RIVER TRIAL IAS CONFERENCE 2019.

The 10th IAS Conference on HIV Science – known as IAS 2019 – took place between 21-24 July 2019 in Mexico City, Mexico.

The IAS Conference on HIV Science is the world’s most influential meeting on HIV research and its applications. This biennial conference presents the critical advances in basic, clinical and operational research that moves science into policy and practice. Through its open and inclusive programme development, the meeting sets the gold standard of HIV research featuring highly diverse and cutting-edge studies.

Jakub Kopycinski gave a presentation on the “Lessons from the Research in Viral Eradication of Reservoirs (RIVER) study: Impact of a therapeutic vaccine targeting conserved HIV epitopes on T cell function in treated primary infection.”

Download Jakub’s full presentation here.

John Frater gave a presentation on “Primary HIV infection: An opportunity not to be missed?”

Download John’s full presentation here.

Find more information on this conference by visiting the IAS website on: http://www.ias2019.org/ 

Jasmini Alagaratnam presented a the results on the “shock and kill” HIV cure strategy.

“Shock and kill” is a HIV cure strategy being investigated, but the safety of “shock and kill” strategies, especially in the brain, is unknown. Blood neurofilament light chain protein (NfL) is a new research marker that can be used to measure brain neuronal injury.

In order to investigate the impact of “shock and kill” on brain neuronal injury, we used stored blood samples from participants in the RIVER trial, comparing the impact of HIV treatment alone versus HIV treatment plus “shock and kill”.

We found no significant difference in plasma NfL by study arm and for up to 6 weeks following the “shock and kill” intervention.

In conclusion, in this first “shock and kill” trial in early HIV disease, we saw no evidence of increased brain neuronal injury following the intervention, using plasma NFL as a surrogate biomarker.

Find Jasmini’s study poster here